Does image quality of the lens affect "focus and recompose" technique?

As I understand it, 'focus and recompose' is often used to ensure the subject is in focus and at the same time composition is right. It has been estimated that some lenses are best in terms of image quality at the center and soft/blurry towards the edges at wide open apertures. When I am using these lenses if I focus and recompose a portrait at a lens's lowest aperture (not necessarily the sweetest aperture value) and put the person to one side will the portrait be sharper or softer in this case?